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Women who remained free from nonfatal myocardial infarction or fatal CHD at the 10-year mark were followed for about 16 more years, during which time researchers identified 386 incident cases of CHD and randomly selected one matched control for each.11 Overall, a greater increase in L-carnitine over the initial 10 years was related to a 36% higher risk of CHD in the subsequent follow-up, regardless of the initial L-carnitine levels

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Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia